Yeast infections may be out of the medicine closet, but they can still make an audience squirm. And that’s just what the comedy team Nude Coffee is after.

“Is it lumpy like cottage cheese?” asks an impatient Mele.

Best of Chicago voting is live now. Vote for your favorites »

“Yes,” Hill answers. The audience groans. A few guys in the front row slap one another on the shoulder; women nod.

Hill and Mele, together with Claire Kaplan, are comediennes and performance artists who bill themselves as rude and crude. But Nude Coffee goes beyond shock value. Most women comediennes try to relate to women by focusing on men: how women are different from men, don’t understand men, or don’t like them. Nude Coffee digs deeper, attempting to describe what life is like for women regardless of their relationship to men.

“No, no, no. That was a prescription,” Mele giggles.

“I love you guys, too,” Hill says, “I really do.”